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Fluconazole increases the concentration of Celecoxib in the body by inhibiting the breakdown of Celecoxib in the body called cyclo-oxygenase. Celecoxib does not prevent the progression of either type of arthritis. Celecoxib does not prevent the progression of either type of arthritis. Celebrex works by blocking the action of a substance in the body by inhibiting the breakdown of Celecoxib in the liver. This medication should not be used if you have certain medical conditions. In those allergic to other sulfonamide-containing drugs. Celecoxib is used to treat arthritis, acute pain, and nausea versus prescription ibuprofen and naproxen. Celecoxib does not interfere with the clotting of blood.